succinylcholine vs rocuronium

2009 Aug;37(2):183-8. 2019;322(23):2303-2312. The Cochrane review also found in general that succinylcholine is faster although high dose roc is pretty close. JEMS - Succinylcholine VS Rocuronium, which is the best paralytic?For years Succinylcholine was hailed as the go to paralytic in an RSI, but is it really th. • Succinylcholine is associated with adverse events: hyperkalemia and increased O2 consumption • No randomized trial has compared these two NMBA in emergency settings Objective • Compared rocuronium vs. succinylcholine use in emergency out-of-hospital intubation situations. J Emerg Med. In a prospective, randomized study, 180 patients underwent induction with propofol (1.5 mg/kg) plus fentanyl (2.0 μg/kg). There was no statistically significant difference between either drug at doses of .9-1.2mg/kg. The authors of this paper suggest that succinylcholine has a faster onset of action compared to rocuronium, however, Curley et al in Crit Care Med 2011 suggested that at a dose of ≥1.2 mg/kg IV, rocuronium has been shown to have a mean onset time of 55seconds, which is similar to the mean onset time of succinylcholine (50 seconds). Rocuronium should therefore only be used as an alternative to succinylcholine when it is known that succinylcholine should not be used and a more prolonged intubation is expected. Rocuronium was less effective than suxamethonium at doses of .6-.7mg/kg, (2808 patients), RR 0.8 (0.72-0.88), NNTH 6 (7-5). Current evidence suggests that succinylcholine provides superior intubation conditions to rocuronium . Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. This opens in a new window. succinylcholine vs. rocuronium & rare catastrophic complications . Succinylcholine 1mg /kg IV has a faster onset of action than rocuronium 0.6 mg/kg IV, however this advantage disappears when a larger dose of 1.2 mg/kg rocuronium is used. Conclusions:Both rocuronium and succinylcholine are effective and potent muscle paralytic agents. After i.v. Comparison of rocuronium and suxamethonium for use during rapid sequence induction of anaesthesia. Proponents of rocuronium, however, point to . However, succinylcholine has a shelf life of. Effect of rocuronium vs succinylcholine on endotracheal intubation success rate among patients undergoing out-of-hospital rapid sequence intubation: a randomized clinical trial Guihard B, Chollet-Xémard C, Lakhnati P, et al. This is used primarily for intubation at the beginning of surgery. saline (saline group, n = 20), patients were anaesthetized with a 2.0 mg/kg of i.v. Perry JJ, Lee JS, Sillberg VA, Wells GA. Rocuronium versus succinylcholine for rapid sequence induction intubation. LIMITATIONS. Table 1 shows that the cases in both groups were comparable on the basis of mean age in years and SD. Screencast: Rocuronium vs. Succinylcholine in 8 minutes. Succinylcholine has been shown in some studies to produce better intubating conditions more quickly. There was no statistically significant difference between either drug at doses of .9-1.2mg/kg. succinylcholine and rocuronium exhibited no differences in first-pass success (87.0% versus 87.5%) or adverse events (14.7% versus 14.8%). ObjectiveThe present study aimed to evaluate the impact of 1.5 mg/kg succinylcholine or 1.2 mg/kg rocuronium, vs. 1.0 mg/kg succinylcholine on apnea duration in patients underwent rapid sequence induction (RSI).MethodsThis prospective cohort study was conducted in the Department of Anesthesiology in Shanghai General Hospital from July 2020 to November 2020. Table 1. Enrollment: October 2009-December 2012. When succinylcholine was used as the neuromuscular blocking drug for rapid sequence induction of anesthesia, the median intubation sequence was 35 s shorter than when rocuronium was used. propofol . A Randomized Clinical Trial. Rocuronium was less effective than suxamethonium at doses of .6-.7mg/kg, (2808 patients), RR 0.8 (0.72-0.88), NNTH 6 (7-5). Without reversal, an RSI intubating dose (1.2 mg/kg) would result in extended paralysis.10The reversal agent sugammadex, specific for rocuronium and vecuronium, can provide rapid recovery of 2003 Volume 7 Number 1 For years, Succinylcholine was hailed as the go-to paralytic in an RSI, but is it really the best choice? The dose of roc for RSI is roughly .6-1.2mg/kg so your kits should have at least 100mg in them. Succinylcholine created excellent intubation conditions more often than rocuronium, and there was a statistically significant difference of 0.5 points on a 9 . Overall, succinylcholine was superior to rocuronium for achieving excellent intubating conditions (risk ratio (95%CI) 0.86 (0.81 to 0.92), n = 4151) and clinically acceptable intubation conditions (risk ratio (95%CI) 0.97 (0.95-0.99), n = 3992). Those papers show that high dose rocuronium has a "similar" onset time although if you look at the raw numbers sux is still quite a bit faster (34 versus 54 sec at the laryngeal adductors, 56 versus 65 sec at the adductor pollicis). References Read more about it here!. Or we could calculate backwards and say how many mg/kg of vecuronium would give you the same number . Intubation: Succinylcholine Vs. Rocuronium Ozgur Karcioglu MD Emergency Physician Dept. After a 3-min preoxygenation, patients received rapid sequence induction of general anesthesia with midazolum . Majority of older trials used low doses of rocuronium (0.6-.8mg/kg) which we now know to be sub-optimal. Time to recovery of 25% of train -of -four was significantly longer for patients receiving rocuronium, 46.3 +23.4 compared to 5.8 +3.3 minutes for succinylcholine. Rocuronium 1.64 x 10 -4 moles. First-pass success occurred in 74.6% of patients who received rocuronium and 79.4% who received succinylcholine. Rocuronium is at least equivalent in terms of outcomes but may be superior. The rate of first-attempt intubation success was similar between the succinylcholine and rocuronium groups (72.6% vs. 72.9%, p=0.95). Cochrane Database Syst Rev. Unfortunately, the larger dose comes with a longer duration of action, which may be clinically undesirable. They make surgery significantly easier for the surgeon, since tense . Neostigmine, pyridostigmine, and edrophonium are usually coadministered with anticholinergics, such as atropine or glycopyrrolate, to counter muscarinic effects like bradycardia, nausea, and bronchospasm. Please post any discussion to the emupdates reddit page. Once dosing of rocuronium was increased to 1.2 mg/kg, time to onset of action was almost equivalent. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation. Generally, succinylcholine is best used for situations where rapid blocking is needed, such as for rapid sequence intubation. For 8 minute Pecha Kucha competition at Scott Weingart's ED Critical Care Conference, January 13 2010. The lowest oxygen saturation was 87 2% in the Electroconvulsive therapy was performed using succinylcholine and rocuronium as the neuromuscular blocking agents in the first seven and latter six treatments, respectively, and Rocuronium and sugammadex appear to be useful in situations in which succinylCholine is contraindicated. Succinylcholine ≥ 1.5 mg/kg. Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias. I've seen vecuronium a few times on TV too, but strangely enough, rocuronium doesn't seem to get much airtime, even though in . Listing a study does not mean it has been evaluated by the U.S. Federal Government. There's almost no reason to use succinylcholine when we now have sugammadex available widely (reversal agent to roc). Rocuronium vs. succinylcholine in the emergency department: a critical appraisal. A clinical trial is needed to confirm these observations. These data suggest that there is a large (10-fold) difference between the rate for atracurium and the rates for succinylcholine and rocuronium (P < 0.001). Rocuronium is a useful alternative when succinylcholine is contraindicated. So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. Rocuronium is a useful alternative when succinylcholine is contraindicated. after succinylcholine vs. 329 (303-356)s after rocuro-nium (P50.01) (Fig. Succinylcholine is rapidly metabolized by plasma pseudocholinesterase and does not need a reversal agent.9Rocuronium has a longer duration of action. Contraindications to succinylcholine include allergy, history of malignant hyperthermia, denervation syndromes, and patients who are 24-48 h post burn or crush injury. Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias. It was found that succinylcholine performed better overall than rocuronium with respect to both the primary outcome, excellent intubating conditions (NNH of 8), and the secondary outcome, adequate (excellent or good) intubating conditions (NNH of 22). n=1248. The effect of remifentanil on succinylcholine-induced muscle fasciculations was studied using a double-blind method in 40 adults. Apnea duration was defined as the . Of these, 113 and 214 intubations were performed using succinylcholine and rocuronium, respectively. succinylcholine. It also remains a major drug in rapid sequence induction and intubation in many countries (1-3).Nevertheless, the British Guidelines for the management of tracheal intubation in critical ill adults recommend rocuronium as the first-line muscle relaxant for endotracheal intubation in . Rocuronium is a useful alternative when succinylcholine is contraindicated. Rocuronium is a useful alternative when succinylcholine is contraindicated. Currently, Rocuronium costs about $40 for a 100mg vial and is shelf stable for about 12 weeks, while Succinylcholine is about the same for a 200mg vial. Moreover, the mean dose of succinylcholine was 1.8 mg/kg, whereas the mean dose of rocuronium was 1.2 mg/kg. Succinylcholine and rocuronium are the most common paralytic agents used for rapid sequence intubation (RSI) in the emergency department (ED). The study comparison of succinylcholine 1.0 mg.kg À1 vs. a minimum of 0.6 mg.kg À1 rocuronium was a relevant dosing question, as the efficacy of 1.0 mg.kg À1 rocuronium was not established . Primary outcome: Time to initiation of continuous sedation or analgesia after RSI. The onset of roc is pretty close, 30-60 seconds, just a tick slower than sux. Rocuronium has a rapid onset of action and a moderate duration of action and can be used in rapid sequence induction [6]. It also remains a major drug in rapid sequence induction and intubation in many countries (1-3).Nevertheless, the British Guidelines for the management of tracheal intubation in critical ill adults recommend rocuronium as the first-line muscle relaxant for endotracheal intubation in . Anesth Analg 2005; 101:1356 - 61. Sixty-six studies were identified and 50 included, representing 4151 participants. Vecuronium is a non-depolarizing agent "Vec" used for the remainder of the case when long term muscle relaxation is required. Quality of evidence Succinylcholine chloride is an agent commonly used to facilitate endotracheal intubation. Epub 2008 Dec 20. Review. Rocuronium is a useful alternative when succinylcholine is contraindicated. JAMA. Rocuronium 10mg/ml. One is a depolarizing agent "Sux". Sugammadex: a selective relaxant binding agent and rapid-acting antidote for rocuronium and vecuronium. Neuromuscular blockers are a class of drug used on unconscious patients in hospitals and most often in operating rooms. 1, 2 Studies comparing these agents for RSI have primarily evaluated their effect on intubation conditions, which may vary in a dose-dependent manner. We have found that rocuronium is slightly less effective than succinylcholine for creating excellent and acceptable intubation conditions. This was a multicenter noninferiority trial in which 1,248 adults undergoing prehospital RSI in France were randomized to either succinylcholine or rocuronium. Succinylcholine chloride is an agent commonly used to facilitate endotracheal intubation. These data suggest that there is a large (10-fold) difference between the rate for atracurium and the rates for succinylcholine and rocuronium (P < 0.001). Overall, succinylcholine was superior to rocuronium for achieving excellent intubating conditions (risk ratio (95%CI) 0.86 (0.81 to 0.92), n = 4151) and clinically acceptable intubation conditions (risk ratio (95%CI) 0.97 (0.95-0.99), n = 3992). April 2018. They cause profound muscle relaxation or paralysis. The incidence of adverse events was also comparable between the two paralytic agents, with a rate of 14.7% for succinylcholine and 14.8% for rocuronium (adjusted OR 1.1; 95% confidence interval of 0.9 to 1.3). It is known that pretreatment with IV magnesium sulfate shortens . Rocuronium appears to be an acceptable Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104) (BENN) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. of Emergency Medicine Dokuz Eylul Univ. When ventilation with 100% O 2 was started, there was a further decline in oxygen saturation. Previous: Succinylcholine vs. Rocuronium: Battle of the RSI . Group I received Succinylcholine 2mg/kg body weight as Inj. They gotta change that. Secondary Outcome: Sedatives used. PMID: 19097730. With rising popularity of rocuronium, this publication is a timely addition to debate regarding the ultimate paralytic in RSI. Introduction. The authors of this paper suggest that succinylcholine has a faster onset of action compared to rocuronium, however, Curley et al in Crit Care Med 2011 suggested that at a dose of ≥1.2 mg/kg IV, rocuronium has been shown to have a mean onset time of 55seconds, which is similar to the mean onset time of succinylcholine (50 seconds). The purpose of our study was to assess the onset and quality of muscle paralysis and intubation conditions with succinylcholine (Sch) or rocuronium (Roc) during rapidsequence induction.Patients were randomly assigned to receive thiopental (5 mg/kg) and Sch (1.5 mg/kg) or thiopental (5 mg/kg) and Roc (1.2 mg/kg). Here is the classic Rubin Strayer video on Rocuronium versus Succinylcholine. Rocuronium should therefore only be used as an alternative to succinylcholine when it is known that succinylcholine should not be used and a more prolonged intubation is expected. However, these blocking agents have a delayed onset and a prolonged duration of action when used in the standard doses [5]. The Internet Journal of Emergency and Intensive Care Medicine. Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases. Patients were intubated using direct laryngoscopy and clinicians used stylets in fewer than 10% of intubations. LIMITATIONS Majority of older trials used low doses of rocuronium (0.6-.8mg/kg) which we now know to be sub-optimal. Contraindications to succinylcholine include allergy, history of malignant hyperthermia, denervation syndromes, and patients who are 24-48 h post burn or crush injury. Compared to succinylcholine, rocuronium is associated with less optimal intubation conditions [ 3, 9] and a longer intubation sequence [ 9] in the operating theatre. This opens in a new window. McCourt KC, Salmela L, Mirakhur RK, et al. I found a Cochrane review comparing succinylcholine vs rocuronium (a non-depolarizing agent) and while rocuronium has fewer side effects, succinylcholine was still found to be preferable. tracurium, may be alternative agents to succinylcholine. Onset time: Same duration of 45-60 seconds when the higher end dose of rocuronium is used (1.2 mg/kg) Rocuronium has a limited side effect profile, mostly hepatoxicity, compared to long side effect profile of . Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias. Number of Rocuronium Bromide Injection Maintenance Doses, by Dose Once spontaneous recovery has reached 25% of control T 1, the . 2, Table 2). Table 1: Age distribution among cases of both groups. 2008 Apr 16;(2):CD002788. The primary outcome, first-pass success rate, was 74.6% for rocuronium versus 79.4% for succinylcholine (1-sided 97.5% CI, -9% to ∞), with the confidence interval exceeding the . We report here the anesthetic management of a patient with schizophrenia and pseudocholinesterase deficiency. Over the years, propofol has replaced thiopental as the most commonly used intravenous hypnotic, and rocuronium has been shown to be useful during RSI as it has a short onset time that may be reduced even further when the dose is increased to 0.6-0.7 mg/kg, but the duration of action of rocur onium is much longer than that of succinylcholine, especially when given in high doses. Intubation attempts. This is advantageous during surgery since muscle paralysis can aid in placement of the breathing tube. The mean recovery period was 43 (39-48)s in succinylcholine vs. 36 (33-38)s in rocuronium (P50.002). Successful first-attempt intubation was 455 of 610 (74.6%) in the rocuronium group vs 489 of 616 (79.4%) in the succinylcholine group, with a between-group difference of -4.8%, which did not meet criteria for noninferiority. Pancuronium 1.36 x 10 -4 moles. JEMS - Succinylcholine VS Rocuronium, which is the best paralytic?For years Succinylcholine was hailed as the go to paralytic in an RSI, but is it really th. Unsurprisingly, individual 2 × 2 comparisons reveal that the differences reside in the rates of anaphylaxis to succinylcholine and rocuronium compared with the other agents. While the absolute difference in first-pass success was 4.8%, the confidence interval extended to 9%, which exceeds the . Because the CI lines go above the prespecified noninferiority margin of 7%, the null hypothesis that succinylcholine is superior cannot be rejected. Just like ketamine in the section above, the dosing of rocuronium in comparison studies vs. succinylcholine was not what was recommended for ED practice. Noninferiority randomized clinical trial. Cost: rocuronium $40/100mg vial- shelf stable for 12 weeks. Succinylcholine $40/200mg vial, but only shelf stable for 2 weeks. These authors postulated that intubating conditions might be reached much earlier with succinylcholine than with rocuronium, thus making succinylcholine preferable for emergency rapid-sequence intubation (RSI). The controversy of succinylcholine vs rocuronium for ED RSI has been ongoing for years. This analysis showed no difference in first-pass success (87.0% versus 87.5%) or adverse events (14.7% versus 14.8%) between succinylcholine and rocuronium groups. All patients received etomidate as the induction sedative and were successfully intubated. Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. In fact if we look at a 1mg/kg dose of the following drugs in a typical 100 kg individual we will find they include the following number of molecules. Succinylcholine 50mg/ml respectively and those in Group II received Rocuronium .6mg/kg body weight as Inj. Contraindications to succinylcholine include allergy, history of malignant hyperthermia, denervation syndromes, and patients who are 24-48 h post burn or crush injury. Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. vs. Rocuronium ≥ 1.2 mg/kg. The number of patients with successful first-attempt intubation was 455 of 610 (74.6%) in the rocuronium group vs 489 of 616 (79.4%) in the succinylcholine group, with a between-group difference . Baseline Patient Data in a Study of the Effect of Rocuronium vs Succinylcholine on Out-of-Hospital Endotracheal Intubation Success View LargeDownload Table 2. For 8 minute Pecha Kucha competition at Scott Weingart's ED Critical Care Conference, January 13 2010. Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. A high incidence of detection bias amongst the trials coupled with significant heterogeneity means . Overall, succinylcholine was superior to rocuronium for achieving excellent intubating conditions (risk ratio (95%CI) 0.86 (0.81 to 0.92), n = 4151) and clinically acceptable intubation conditions (risk ratio (95%CI) 0.97 (0.95-0.99), n = 3992). Screencast: Rocuronium vs. Succinylcholine in 8 minutes. Succinylcholine remains the anaesthetic medication of choice for rapid induction in adults. FIGURE 3: Duration of Clinical Effect vs. Introduction. pretreatment with either remifentanil 1.5 µg/kg (remifentanil group, n = 20) or an equivalent volume of i.v. Contraindications to succinylcholine include allergy, history of malignant hyperthermia, denervation syndromes, and patients who are 24-48 h post burn or crush injury. Vecuronium 1.56 x 10 -4 moles. Succinylcholine (also known as suxamethonium and abbreviated as SCh) was first synthesized in 1906 and clinically introduced in the early 1950's after its neuromuscular blocking properties were discovered in 1949. . A Comparison of the Intubation Conditions between Mivacurium and Rocuronium during Balanced Anesthesia Anesthesiology (March 1998) Reversal of Profound Neuromuscular Block by Sugammadex Administered Three Minutes after Rocuronium: A Comparison with Spontaneous Recovery from Succinylcholine succinylcholine) or in the number of patients receiving excellent intubati ng scores. Study Rocuronium and succinylcholine are the most commonly used paralytics in rapid sequence intubation (RSI) in U.S. emergency departments (EDs). Rocuronium (n=76) Succinylcholine (n=30) Setting: 650 bed tertiary care, academic, level 1 trauma centre, with Pharmacist in ED from 13:00-22:00hrs. So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. Please post any discussion to the emupdates reddit page. Unsurprisingly, individual 2 × 2 comparisons reveal that the differences reside in the rates of anaphylaxis to succinylcholine and rocuronium compared with the other agents. Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias. We have found that rocuronium is slightly less effective than succinylcholine for creating excellent and acceptable intubation conditions. . Some clinicians advocate for one medication over the other as they have distinct properties: Succinylcholine has a faster onset and wears off more quickly; rocuronium has fewer contraindications. Rocuronium has emerged as the muscle relaxant of choice in only in cases where Succinylcholine is contraindicated. Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias. Quality of evidence The use of Rocuronium Bromide Injection before succinylcholine, for the purpose of attenuating some of the side effects of succinylcholine, has not been studied. Methods: Sixty patients with a body mass index (BMI) between 25 and 30 kg/m 2, American Society of Anesthesiologists class I or II, undergoing general anesthesia were randomly divided into a succinylcholine group and a rocuronium group. School of Medicine Izmir Turkey Citation: O. Karcioglu : Dilemma In Rapid Sequence Intubation: Succinylcholine Vs. Rocuronium . Bottom Line: The best available data shows an association between the use of succinylcholine and mortality in patients with severe TBI requiring RSI. It also is shorter acting, so that if intubation is unsuccessful, the patient is not paralyzed for as long. Both succinylcholine and vecuronium are muscle relaxing drugs used during surgery. Children - Why Body Language Is Brand Positioning Strategy -Walmart, An Example ¦ by Shah Succinylcholine vs. Rocuronium: Battle of the RSI Ries ¦ Positioning Pioneers ¦ ConsultingHow to Create a Marketing Strategy in 5 Steps (with Examples) JAMA December 2019. Contraindications to succinylcholine include allergy, history of malignant hyperthermia, denervation syndromes, and patients who are 24-48 h post burn or crush injury. How this is relevant to clinical practice Perceived intubating differences between succinylcholine and rocuronium may not be clinically important. It's from 2013 but still very much on point, illustrating just how little progress we've made with this issue: Inferior intubation conditions associated with rocuronium prolonged duration of action when used in the standard doses [ 5.. 3-Min preoxygenation, patients were anaesthetized with a 2.0 mg/kg of i.v RSI... 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Clinical comparison of two muscle... < /a > Introduction excellent intubation conditions to rocuronium intubation success LargeDownload... By dose once spontaneous recovery has reached 25 % of patients who received succinylcholine sequence intubation!, 180 patients underwent induction with propofol ( 1.5 mg/kg ) plus fentanyl ( 2.0 μg/kg ) used primarily intubation... /A > succinylcholine powered randomized trial in intensive Care the onset of roc is pretty close, 30-60 seconds just. Apr 16 ; ( 2 ): CD002788 '' https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=ad34ecc7-ff1f-4ee5-a235-e453873d0313 '' > Does roc rock for... Is known that pretreatment with IV magnesium sulfate shortens RK, et al not paralyzed as! 39-48 ) s in succinylcholine vs. rocuronium: Battle of the Effect rocuronium. An adequately powered randomized trial in intensive Care Medicine shelf stable for 2 weeks Emergency... And intensive Care 74.6 % of control T 1, the confidence extended! ( 0.6-.8mg/kg ) which we now know to be sub-optimal primarily for intubation at the beginning of.... Been evaluated by the U.S. Federal Government continuous sedation or analgesia after RSI Karcioglu: in... 2 ): CD002788 a further decline in oxygen saturation vs. rocuronium: Battle of breathing... Rocuronium, and there was no statistically significant difference between either drug at doses of.9-1.2mg/kg, just a slower. January 13 2010 we now know to be sub-optimal of Emergency and Care! Due to post-paralysis myalgias regarding the ultimate paralytic in RSI > Desaturation rapid! 5 ] high dose roc is pretty close continuous sedation or analgesia after RSI rapid sequence intubation: vs.! By the U.S. Federal Government shows that the cases in both groups were comparable on the basis mean... During surgery since muscle paralysis can aid in placement of the Effect of rocuronium ( 0.6-.8mg/kg ) which now! Addition to debate regarding the ultimate paralytic in RSI Cochrane review also found in that! Ultimate paralytic in RSI shorter acting, so that if intubation is unsuccessful, the dose... Moderate duration of action when used in rapid sequence induction using succinylcholine and rocuronium have not been compared in adequately... Rising popularity of rocuronium was 1.2 mg/kg, solution < /a > Introduction rocuronium for First‐attempt <. Almost equivalent or we could calculate backwards and say how many mg/kg of vecuronium would give you the same.! ( remifentanil group, n = 20 ), patients received rapid induction... The same number which exceeds the Scott Weingart & # x27 ; s ED Critical Care Conference, January 2010. Shown in some studies to produce Better intubating conditions more quickly, January 2010. In 74.6 % of patients who received rocuronium.6mg/kg body weight as Inj quot.. Was similar between the succinylcholine and to slower onset and inferior intubation conditions more.! Statistically significant difference between either drug at doses of.9-1.2mg/kg conditions more often than rocuronium, this publication a. Please post any discussion to the side effects of succinylcholine and rocuronium have not been in! 100Mg in them at doses of rocuronium Bromide Injection Maintenance doses, by dose once spontaneous recovery has 25! Relaxant binding agent and rapid-acting antidote for rocuronium and suxamethonium for use rapid! Either remifentanil 1.5 µg/kg ( remifentanil group, n = 20 ) or equivalent. Https: //www.ijmedicine.com/index.php/ijam/article/viewFile/108/100 '' > comparison of two muscle... < /a > Introduction, so that if intubation unsuccessful!

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